If I am not mistaken, this is the first time a pharmaceutical company is doing a study to see what the real challenges or obstacles diabetics encounter in a typical day that derails them from implementing their prescribed treatment.

Hopefully, the results of the study will provide some practical solutions for people with diabetes. As we know, managing the ups and downs of blood glucose is key to prevent complications down the road such as blindness, heart attacks, kidney disease, amputations, etc.

The National Institutes of Health are providing us a post dated December 2 that indicates the general outline of the study and its goals

Lilly, Med Centers to Study Type 2 Diabetes Obstacles

Eli Lilly and Company, the Indianapolis pharmaceutical maker, is conducting a study to better understand real-world obstacles that keep people with type 2 diabetes from reaching their treatment goals. In the MOSA1c study — short for Multinational Observational Study Assessing Insulin use: Understanding the challenges associated with the progression of therapy — Lilly is partnering with Brigham and Women’s Hospital in Boston and Harvard Medical School.

As diabetes progresses, people often need to intensify their treatment by increasing their insulin to avoid spikes in blood sugar level that can damage blood vessels. MOSA1c seeks to find out why many people with diabetes who take daily insulin resist this progression of insulin therapy that could help them reach their ideal blood sugar target.

This resistance, documented in studies worldwide, exposes type 2 diabetes patients to an increased risk of serious complications, such as blindness, amputation, heart disease, and kidney failure. Research so far has documented the factors keeping people with diabetes from moving to insulin from oral medications, but there is little data to help understand the barriers to insulin intensification.

The study plans to gather data on insulin use, interactions between people with and treating diabetes, and other factors involved in the progression of treatments used to manage diabetes. The data are expected to cover:

Factors associated with adherence to insulin therapy, including patient and physician characteristics, treatment regimen and cost, as treatment intensifies

Geographic and cultural differences that may have an impact on progression of insulin therapy

Reasons reported by patients and physicians for progression or discontinuation of therapies

Rates of low blood sugar (hypoglycemia) in patients who stay on initial insulin therapy compared to those who increase insulin use.

The research will follow some 4,500 people with type 2 diabetes taking insulin in the U.S. and 16 other countries for two years. Participant recruitment began in July 2011. Interim results from the MOSA1c study are expected to be available in mid-2012.

To your success in managing your health condition!


I am Andy Carpenter and I would start by saying that I have a Bachelor Degree in Nutrition Science conferred by California State University, Los Angeles and that I am certified as a Registered Dietitian.

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